Longitudinal proteomic profiling of the inflammatory response in dengue patients.
Fadel Muhammad GarishahCollins K BoahenNadira VadaqSetyo G PramudoRahajeng N TunjungputriSilvita Fitri RiswariRonald P van RijBachti AlisjahbanaMuhammad Hussein GasemAndré J A M van der VenQuirijn de MastPublished in: PLoS neglected tropical diseases (2023)
We identified 203 upregulated and 39 downregulated proteins in acute versus convalescent plasma samples. The upregulated proteins had a strong representation of interferon (IFN) and IFN-inducible effector proteins, cytokines (e.g. IL-10, IL-33) and cytokine receptors, chemokines, pro-apoptotic proteins (e.g. granzymes) and endothelial markers. A number of differentially expressed proteins (DEPs) have not been reported in previous studies. Functional network analysis highlighted a central role for IFNγ, IL-10, IL-33 and chemokines. We identified different novel associations between inflammatory proteins and circulating concentrations of the endothelial glycocalyx disruption surrogate marker syndecan-1. Conclusion: This unbiased proteome analysis provides a comprehensive insight in the inflammatory response in DENV infection and its association with glycocalyx disruption.