FeSe2 nanosheets as a bifunctional platform for synergistic tumor therapy reinforced by NIR-II light.
Lan FangJie WangXueliang OuyangBinbin LiangLiying ZhaoDechun HuangDawei DengPublished in: Biomaterials science (2021)
Multi-functionality has been a constant pursuit in the development of next-generation drug carriers, as it will bring the potential for combination therapy by integrating diverse therapeutic modes. In this work, FeSe2 nanosheets (NSs) have been prepared as a bifunctional platform to investigate their use in synergistic cancer therapy. Bifunctional FeSe2 NSs exhibit exceptional Fenton-like activity that generates cytotoxic hydroxyl radical (˙OH) and strong broad photothermal performance including the second-infrared (NIR-II) spectral range, wherein the ˙OH production can be enhanced by NIR-II light irradiation. Furthermore, doxorubicin (DOX) was conjugated onto NSs via a pH-responsive hydrazone bond to achieve preferential drug release in an acidic microenvironment. Upon intratumoral administration, these bifunctional drug-carrying FeSe2 NSs showed an NIR-II irradiation-reinforced strong tumor suppression effect, and no obvious toxicity to normal tissues was observed. This study provides a new paradigm for the design of advanced drug carriers relying on their inherent physicochemical properties.
Keyphrases
- drug release
- cancer therapy
- drug delivery
- photodynamic therapy
- highly efficient
- metal organic framework
- combination therapy
- fluorescence imaging
- fluorescent probe
- emergency department
- drug induced
- gene expression
- oxidative stress
- stem cells
- reduced graphene oxide
- nitric oxide
- mesenchymal stem cells
- wastewater treatment
- magnetic resonance imaging
- gold nanoparticles
- climate change
- magnetic resonance
- risk assessment
- optical coherence tomography
- radiation therapy
- human health