Nisin Induces Cell-Cycle Arrest in Free-Living Amoebae Acanthamoeba castellanii.

Marianna de Carvalho ClímacoYrna Lorena Matos de OliveiraAnne Caroline Santos RamosJucicleide Ramos-de-SouzaAudrey Rouse Soares Tavares SilvaSona JainMarilise Brittes RottRicardo ScherCristiane Bani CorreaAna Andrea Teixeira BarbosaSilvio Santana Dolabella

Published in: Acta parasitologica (2021)

This is one of the first studies showing the effect of internationally approved nisin against A. castellanii trophozoites. Nisin caused cell-cycle arrest in trophozoites, momentarily interfering with the DNA replication process. The data highlight the amoebostatic activity of nisin, and suggest its use as an adjuvant for the treatment of infections caused by Acanthamoeba spp.

Keyphrases

cell cycle arrest
cell death
pi k akt
signaling pathway
early stage
electronic health record
big data
machine learning
case control
deep learning
data analysis