Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
Elena BuelowTeresita D J Bello GonzálezSusana FuentesWouter A A de Steenhuijsen PitersLeo LahtiJumamurat R BayjanovEline A M MajoorJohanna C BraatMaaike S M van MourikEvelien A N OostdijkRob J L WillemsMarc J M BontenMark W J van PasselHauke SmidtWillem van SchaikPublished in: Microbiome (2017)
The gut microbiota of SDD-treated ICU patients deviated strongly from the gut microbiota of healthy subjects. The negative effects on the resistome were limited to selection for four resistance genes. While it was not possible to disentangle the effects of SDD from confounding variables in the patient cohort, our data suggest that the risks associated with ICU hospitalization and SDD on selection for antibiotic resistance are limited. However, we found evidence indicating that recolonization of the gut by antibiotic-resistant bacteria may occur upon ICU discharge and cessation of SDD.
Keyphrases
- intensive care unit
- mechanical ventilation
- newly diagnosed
- end stage renal disease
- chronic kidney disease
- genome wide
- case report
- prognostic factors
- single cell
- electronic health record
- human health
- patient reported outcomes
- gene expression
- climate change
- machine learning
- acute respiratory distress syndrome
- dna methylation
- genome wide identification