Login / Signup

CYP2C19 phenotype in South-East Asian Acute Coronary Syndrome patients and impact on major adverse cardiovascular events.

Doreen Su Yin TanJernice Wan Xin AwMichael WintherLiuh Ling GohHean Yee OngEric WeeJianjun LiuHan Kiat Ho
Published in: Journal of clinical pharmacy and therapeutics (2019)
In our multivariate analysis, LoF-Clopidogrel, malay ethnicity, diabetics and use of proton pump inhibitors were independent predictors of MACE. There were numerically more bleeds in LoF subjects who were on prasugrel compared with Clopidogrel (23.5% vs 11%, P = .082). Our data corroborate with current findings on platelet reactivity testing, suggesting that the assay would not be sensitive enough to pick up sufficient 'at-risk' subjects as compared to the use of CYP2C19 genotyping.
Keyphrases