Impaired muscle uptake of creatine in spinal and bulbar muscular atrophy.
Yasuhiro HijikataMasahisa KatsunoKeisuke SuzukiAtsushi HashizumeAmane ArakiShinichiro YamadaTomonori InagakiMadoka IidaSeiya NodaHirotaka NakanishiHaruhiko BannoTomoo ManoAkihiro HirakawaHiroaki AdachiHirohisa WatanabeMasahiko YamamotoGen SobuePublished in: Annals of clinical and translational neurology (2016)
These results suggest that low serum Cr concentration in subjects with SBMA is caused by impaired muscle uptake of creatine in addition to being caused by neurogenic atrophy. Given that creatine serves as an energy source in skeletal muscle, increasing muscle creatine uptake is a possible therapeutic approach for treating SBMA.