Withdrawal from acute medication normalises short-term cortical synaptic potentiation in medication overuse headache.

Francesca CorteseFrancesco PierelliFlavia PauriCherubino Di LorenzoChiara LepreGiulia MalavoltaChiara MerluzzoVincenzo ParisiAnna AmbrosiniMariano SerraoGianluca Coppola

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2019)

The results suggest that acute medication withdrawal normalises brain responses in patients with MOH. Clinical improvements after medication withdrawal may reflect the reversal of neurophysiological dysfunction. Accordingly, medication withdrawal should be offered to patients with MOH as early as possible in order to prevent the development of more pronounced alterations in brain plasticity.

Keyphrases

adverse drug
healthcare
liver failure
respiratory failure
drug induced
aortic dissection
intensive care unit
brain injury
acute respiratory distress syndrome
electronic health record
subarachnoid hemorrhage