Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?

Dinko Hauptman Marta Himelreich PerićTihana MarićAna Katušić BojanacNino SinčićZoran ZimakŽeljko KaštelanDavor Jezek

Published in: Life (Basel, Switzerland) (2021)

The decrease in the number of Leydig cells can be explained by previous inflammatory changes within the testicular interstitium and consequent interstitial fibrosis. The interstitial fibrosis might have a deteriorating effect on Leydig cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
cell death
signaling pathway