Parkinson's disease GWAS-linked Park16 carriers show greater motor progression.

Xiao DengBin XiaoJohn Carson AllenEbonne NgJia-Nee FooYew-Long LoLouis C S TanEng King Tan

Published in: Journal of medical genetics (2019)

In a 9-year longitudinal study, we demonstrated that PD PARK16 variant carriers exhibited greater motor progression after 5 years of disease compared with non-carriers, suggesting that GWAS-linked gene variants may influence disease progression over time. Closer monitoring and management of these higher risk patients can facilitate a better quality of life.

Keyphrases

end stage renal disease
copy number
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
genome wide association study