Brain Metabolism and Amyloid Load in Individuals With Subjective Cognitive Decline or Pre-Mild Cognitive Impairment.
Giacomo TondoCecilia BoccaliniEmilia Giovanna VanoliLuca PresottoCristina MuscioValentina CiulloNerisa BanajFederica PirasGraziella FilippiniPietro TiraboschiFabrizio TagliaviniGiovanni Battista FrisoniStefano Francesco CappaGianfranco SpallettaDaniela Peraninull nullPublished in: Neurology (2022)
FDG-PET evidence suggests either normal brain function or different patterns of brain hypometabolism in SCD and pre-MCI subjects. These results indicate that SCD and pre-MCI represent heterogeneous populations. Consistently, different neuropsychological and neuropsychiatric profiles emerged, which correlated with neuronal dysfunction in specific brain regions. Long-term follow-up studies are needed to assess the risk of progression to dementia in these conditions.