Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases.

Matthew M GrabowskiEthan S SrinivasanEugene J VaiosEric W SankeyBalint OtvosDaria KrivosheyaAlex ScottMichael OlufawoJun MaElena I FomchenkoJames E HerndonAlbert H KimVeronica L ChiangClark C ChenEric C LeuthardtGene H BarnettJohn P KirkpatrickAlireza M MohammadiPeter E Fecci

Published in: Neuro-oncology advances (2022)

These data suggest that LITT+SRT is superior to LITT or repeat SRT alone for treatment of biopsy-proven brain metastasis recurrence after SRT failure. Prospective trials are warranted to validate the efficacy of using combination LITT+SRT for treatment of recurrent brain metastases.

Keyphrases

brain metastases
small cell lung cancer
early stage
stem cells
machine learning
combination therapy
mesenchymal stem cells
big data
artificial intelligence
fine needle aspiration
blood brain barrier
data analysis
functional connectivity