TRPM2 Plays a Minor Role in AKI and Kidney Fibrosis.

TRPM2 is a Ca2 + -permeable cationic channel and serves as an oxidative stress sensor.TRPM2 deletion was harmful in renal ischemia-reperfusion injury, whereas TRPM2 deletion mitigated kidney fibrosis.Our findings suggest the role of TRPM2 in kidney diseases is context dependent.