Surface and global proteome analyses identify ENPP1 and other surface proteins as actionable immunotherapeutic targets in Ewing sarcoma.

Brian Mooney Gian Luca Negri Taras Shyp Alberto Delaidelli Hai-Feng Zhang Sandra Elizabeth Spencer Amber K Weiner Alexander B Radaoui Rawan Shraim Michael M Lizardo Christopher S Hughes Amy Li Amal M El-Naggar Melanie Rouleau Wei Li Dimiter S Dimitrov Raushan T Kurmasheva Peter J Houghton Sharon J Diskin John M Maris Gregg B Morin Poul H Sorensen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our comprehensive proteomic characterization of the EwS surfaceome provides a rich resource of surface-expressed proteins in EwS. This dataset provides the preclinical justification for exploration of targets such as ENPP1 for potential immunotherapeutic application in EwS.

Keyphrases

stem cells
cell therapy
risk assessment
bone marrow
human health