Democrats and independents stigmatize people with COVID-19 greater compared to Republicans.

Messaging about COVID-19 was different across the political spectrum, which influenced differences in attitudes surrounding COVID-19. This study examined the political affiliation/ideology on COVID-19 stigma (blame, deservingness of help, negative emotionality) and two mediators of this relationship: conspiracy beliefs and anxiety about COVID-19. Participants answered questions about their political affiliation and ideology, attitudes toward people who have contracted COVID-19; and COVID-19 conspiracy beliefs and anxiety. Democrats and Independents indirectly stigmatized people with COVID-19 via increased COVID-19 anxiety and fewer COVID-19 conspiracy beliefs relative to Republicans. Politicization can strongly impact stigma, and messaging could be harnessed as a stigma reduction tool.