The Use of Ceramides to Predict Metabolic Response to Metformin in Women With PCOS.
Anu SharmaBenjamin KrickYing LiScott A SummersMary C PlaydonCorrine WeltPublished in: Journal of the Endocrine Society (2022)
Lower total Cer(16:0) and DHSM concentrations are associated with a beneficial metabolic response to metformin in women with PCOS. Based on the known association between higher ceramide levels and type 2 diabetes, the data suggest that metformin improves metabolic parameters in women with mild metabolic derangements.