Hypertrophic Preconditioning Attenuates Myocardial Ischaemia-Reperfusion Injury by Modulating SIRT3-SOD2-mROS-Dependent Autophagy.

Lei-Lei MaFei-Juan KongZheng DongKai-Yue XinXing-Xu WangAi-Jun SunYun-Zeng ZouJun-Bo Ge

Published in: Cell proliferation (2021)

The present study identifies TAC preconditioning as a novel strategy for induction of an endogenous self-defensive and cardioprotective mechanism against cardiac injury. Specifically, TAC preconditioning reduced myocardial autophagic cell death in a SIRT3/SOD2 pathway-dependent manner.

Keyphrases

cell death
ischemia reperfusion injury
cerebral ischemia
left ventricular
oxidative stress
cell cycle arrest
subarachnoid hemorrhage
amyotrophic lateral sclerosis
signaling pathway
acute myocardial infarction
brain injury
genome wide
heart failure
gene expression
cell proliferation
acute ischemic stroke