Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis are tolerized toward TLR2 activation.

Kazumasa Iwamoto Tim J NümmS KochNadine Herrmann Nicole LeibT Bieber

Published in: Allergy (2018)

Our results suggest that TLR2-mediated sensing of S. aureus-derived signals is strongly impaired in LC from AD skin. This phenomenon may partly contribute to the immune deviation in AD and the lack of S. aureus clearance.

Keyphrases

atopic dermatitis
toll like receptor
inflammatory response
induced apoptosis
immune response
wound healing
cell cycle arrest
oxidative stress
nuclear factor
endoplasmic reticulum stress
mass spectrometry
simultaneous determination
cell death
signaling pathway