CD19+ tumor-infiltrating B-cells prime CD4+ T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer.

Qi JiangQiang FuYuan ChangZheng LiuJunyu ZhangLe XuYu ZhuYiwei WangWeijuan ZhangJiejie Xu

Published in: Cancer immunology, immunotherapy : CII (2018)

CD19+ TIB was identified as an independent prognostic factor, which could predict for post-surgery survival and platinum-based ACT benefits in MIBC. CD19+ TIB serve as antigen-presenting cells (APCs) to activate CD4+ TIT in the tumor environment of MIBC.

Keyphrases

prognostic factors
muscle invasive bladder cancer
nk cells
minimally invasive
squamous cell carcinoma
oxidative stress
coronary artery bypass
rectal cancer
free survival