Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty.
Ana Victoria Lechuga-ViecoAna Latorre-PellicerEnrique CalvoCarlos TorrojaJuan PellicoRebeca Acin-PerezMaría Luisa García-GilArnoldo SantosNavratan BagwanElena Bonzón-KulichenkoRicardo MagniMarina BenitoRaquel Justo-MéndezAnna Katharina SimonFátima Sánchez-CaboJesus VazquezJesús Ruíz-CabelloJosé Antonio EnríquezPublished in: Circulation (2022)
Medical interventions that may generate DNPH should address potential incompatibilities between donor and recipient mtDNA.