Modulating T-bet-promoted energy metabolism in pathogenic age/autoimmune-associated B cells ameliorates lupus autoimmunity.

Xiaxia HanShuangshuang GuSoon-Min HongYang JiangJinsong ZhangChao YaoZhihua YinZhizhong YeHuihua DingSheng ChenDai DaiNan Shen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

T-bet can couple immune signals and metabolic programming to establish pathogenic ABC formation and functional capacities. Modulating ABC favored metabolic program could be a novel therapeutic approach for lupus. This article is protected by copyright. All rights reserved.

Keyphrases

systemic lupus erythematosus
disease activity
signaling pathway
quality improvement
multiple sclerosis
mouse model
rheumatoid arthritis