Application of Genomic Sequencing to Refine Patient Stratification for Adjuvant Therapy in Renal Cell Carcinoma.
Naveen S VasudevGhislaine SceloKate I GlennonMichelle WilsonLouis LetourneauRobert Jm EveleighNazanin NourbeheshtMadeleine ArseneaultAntoine PaccardLars EgevadJuris ViksnaEdgars CelmsSharon M JacksonBehnoush Abedi-ArdekaniAnne Y WarrenPeter John SelbySebastian TrainorMichael KimuliJon CartledgeNaeem SoomroAdebanji AdeyojuPoulam Manubhai PatelMagdalena B WozniakIvana HolcatovaAntonin BrisudaVladimír JanoutEstelle ChanudetDavid ZaridzeAnush MukeriyaOxana ShanginaLenka ForetovaMarie NavratilovaDana MatesViorel JingaLjiljana BogdanovicBozidar KovacevicAnne Cambon-ThomsenGuillaume BourqueAlvis BrazmaJorg TostPaul J BrennanMark LathropYasser RiazalhosseiniRosamonde E BanksPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Genomic characterization of ccRCC identified biologically distinct groups of patients with divergent relapse rates. These groups account for the ∼80% of cases with VHL mutations and could be used to personalize adjuvant treatment discussions with patients as well as inform future adjuvant trial design.