RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours.

Thomas LongerichVolker EndrisOlaf NeumannEugen RempelMartina KirchnerZahra AbadiSebastian UhrigMark KriegsmannKarl Heinz WeissKai BreuhahnArianeb MehrabiTim Frederik WeberLudwig WilkensBeate K StraubAndreas RosenwaldFalko SchulzeBenedikt BrorsStefan FroehlingRossella PellegrinoJan BudcziesPeter SchirmacherAlbrecht Stenzinger

Published in: Gut (2019)

The RSPO2 gene rearrangement leads to oncogenic activation of the WNT signalling pathway in HCA and HCC, represents an alternative mechanism for the development of b-HCA and may drive malignant transformation without additional TERT promoter mutation.

Keyphrases

cell proliferation
genome wide
copy number
transcription factor
dna methylation
genome wide identification
stem cells
epithelial mesenchymal transition
signaling pathway