Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer.

Niranjan MeherGary W AshleyKondapa Naidu BobbaAnju WadhwaAnil P BidkarChandrashekhar DasariChanghua MuRamya Ambur SankaranarayananJuan A Camara SerranoAthira RaveendranDavid P BulkleyRahul AggarwalNancy Y GreenlandAdam OskowitzDavid M WilsonYoungho SeoDaniel V SantiHenry F VanBrocklinRobert Richard Flavell

Published in: Advanced healthcare materials (2024)

The StarPEG nanocarriers demonstrated high PSMA-targeted delivery of the therapeutic isotope 177Lu with excellent imaging contrast. The targeted nanocarrier eliminated subcutaneous and metastatic PC3-Pip tumors. Overall, these preclinical results demonstrated high treatment efficacy of the PSMA-targeted nanocarrier [177Lu]PEG-(DOTA)1(ACUPA)3 for prostate cancer, with potential for clinical translation. This article is protected by copyright. All rights reserved.

Keyphrases

prostate cancer
drug delivery
cancer therapy
pet ct
radical prostatectomy
pet imaging
high resolution
drug release
squamous cell carcinoma
small cell lung cancer
cell therapy
magnetic resonance imaging
stem cells
risk assessment
positron emission tomography
smoking cessation