Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target.
Silpa GampalaFenil ShahXiaoyu LuHye-Ran MoonOlivia BabbNikkitha Umesh GaneshGeorge SanduskyEmily HulseyLee ArmstrongAmber L MoselyBumsoo HanMircea IvanJing-Ruey Joanna YehMark R KelleyChi ZhangMelissa L FishelPublished in: Journal of experimental & clinical cancer research : CR (2021)
Ref-1 redox signaling inhibition conclusively alters cancer cell metabolism by causing TCA cycle dysfunction while also reducing the pancreatic tumor growth in vitro as well as in vivo.
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