Tantalum-Catalyzed Amidation of Amino Acid Homologues.
Wataru MuramatsuHisashi YamamotoPublished in: Journal of the American Chemical Society (2019)
A tantalum-catalyzed solvent-free approach for the construction of amide bonds with 1-(trimethylsilyl)imidazole is developed, and the mild reaction conditions are applicable to a wide variety of electrophilic amino acid homologues. This approach delivers a new class of peptides in high yields without any epimerization.
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