Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat.

Zhongzhong LiuXingjian ZhangQi XiaoShaojun YeChin-Hui LaiJun LuoXiaoying HuangWei WangCheng ZengZibiao ZhongXiaoli FanZhiping XiaYan XiongXinfang MaoQi-Fa Ye Yanfeng Wang

Published in: Oxidative medicine and cellular longevity (2017)

Pretreatment of DCD donors with simvastatin improves DCD livers' functional recovery probably through a KLF2-dependent mechanism. These data suggest that simvastatin may provide a potential benefit for clinical DCD liver transplantation.

Keyphrases

ischemia reperfusion injury
oxidative stress
transcription factor
electronic health record
big data
mouse model
climate change
artificial intelligence