Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat.
Zhongzhong LiuXingjian ZhangQi XiaoShaojun YeChin-Hui LaiJun LuoXiaoying HuangWei WangCheng ZengZibiao ZhongXiaoli FanZhiping XiaYan XiongXinfang MaoQi-Fa YeYanfeng WangPublished in: Oxidative medicine and cellular longevity (2017)
Pretreatment of DCD donors with simvastatin improves DCD livers' functional recovery probably through a KLF2-dependent mechanism. These data suggest that simvastatin may provide a potential benefit for clinical DCD liver transplantation.