Grape Polyphenols May Prevent High-Fat Diet-Induced Dampening of the Hypothalamic-Pituitary-Adrenal Axis in Male Mice.

Esther MezhibovskyKevin M TveterJose A Villa-RodriguezKaren BacaliaDushyant KshatriyaNikhil DesaiAlrick CabalesYue WuKe SuiRocio M DuranNicholas T BelloDiana E Roopchand

Published in: Journal of the Endocrine Society (2023)

GPs may attenuate HFD-induced weight gain by improving hormonal control of the HPAA and inducing a BA profile with less cytotoxicity and HPAA inhibition, but greater FXR antagonism.

Keyphrases

weight gain
high fat diet induced
insulin resistance
body mass index
birth weight
high fat diet
high glucose
polycystic ovary syndrome
diabetic rats
weight loss
adipose tissue
type diabetes
skeletal muscle
growth hormone
endothelial cells
gestational age