Selection and validation of chemotherapy beneficiaries among elderly nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT): a large real-world study.
Yan-Ling WuKai-Bin YangYing HuangJing-Rong ShiQing-Shui HeLei ChenWen-Fei LiXiao-Dan HuangLi LinYu-Pei ChenYan-Ping MaoLing-Long TangJun MaPublished in: Radiation oncology (London, England) (2022)
For elderly NPC patients a simple screening cutoff for chemotherapy beneficiaries might be EBV DNA < 4000 copies/ml & T3-4 and EBV DNA ≥ 4000 copies/ml & any T, but not for those > 70 years old and with an ACE-27 score > 1. IC + CCRT and CCRT were effective forms of chemotherapy.
Keyphrases
- locally advanced
- radiation therapy
- epstein barr virus
- end stage renal disease
- circulating tumor
- newly diagnosed
- cell free
- diffuse large b cell lymphoma
- ejection fraction
- chronic kidney disease
- middle aged
- single molecule
- prognostic factors
- squamous cell carcinoma
- rectal cancer
- community dwelling
- chemotherapy induced
- nucleic acid
- angiotensin ii
- radiation induced