A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease.
Hieu T NimLouis DangHarshini ThiyagarajahDaniel BakopoulosMichael SeeNatalie CharitakisTennille SibbrittMichael P EichenlaubStuart K ArcherNicolas FossatRichard E BurkePatrick P L TamCoral G WarrTravis K JohnsonMirana RamialisonPublished in: Genome biology (2021)
Our pipeline has enabled the discovery of novel genes with roles in heart development. This workflow, which relies on screening for non-coding cis-regulatory signatures, is amenable for identifying developmental and disease genes for an organ without constraining to genes that are expressed exclusively in the organ of interest.