Isobolographic analysis reveals antinociceptive synergism between Phα1β recombinant toxin and morphine in a model of cancer pain in C57BL/6J mice.

Caio Tavares AokiRodrigo Andrade MouraLuana Assis FerreiraMariana Garcia MendesDuana Carvalho SantosMarcio Junior RezendeMarcus Vinicius Gomez Célio José de Castro

Published in: The journal of venomous animals and toxins including tropical diseases (2021)

The combinatorial use of recombinant Phα1β and morphine allows significant and effective dose reduction of both agents, which has translational potential for opioid-sparing approaches in pain management related to cancer.

Keyphrases

pain management
chronic pain
papillary thyroid
squamous cell
escherichia coli
childhood cancer
robot assisted
metabolic syndrome
young adults
neuropathic pain
skeletal muscle
anti inflammatory
drug induced
wild type