Pico-HPLC system integrating an equal inner diameter femtopipette into a 900 nm I.D. porous layer open tubular column.
Ruonan LiYunlong ShaoYanmin YuXiayan WangGuangsheng GuoPublished in: Chemical communications (Cambridge, England) (2018)
A picoflow high performance liquid chromatography (pico-HPLC) system was developed, which could directly pipette femtoliter samples using a separation column tip driven by an electroosmotic pump. Amino acid enantiomers were separated in the 900 nm I.D. porous layer open tubular column at a flow rate of 13.50 pL min-1.
Keyphrases
- solid phase extraction
- high performance liquid chromatography
- liquid chromatography
- tandem mass spectrometry
- simultaneous determination
- mass spectrometry
- minimally invasive
- amino acid
- photodynamic therapy
- metal organic framework
- high glucose
- highly efficient
- tissue engineering
- ms ms
- endothelial cells
- capillary electrophoresis
- optical coherence tomography