Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism.

Adriana Marques-CarvalhoBeatriz SilvaFrancisco B PereiraHa-Neui KimMaria AlmeidaVilma A Sardão

Published in: European journal of clinical investigation (2024)

These findings elucidate the early effects of RANKL on osteoclast progenitor metabolism and suggest novel p53-mediated mechanisms that contribute to postmenopausal osteoporosis.

Keyphrases

bone loss
bone mineral density
postmenopausal women
oxidative stress
body composition