APOBEC3 as a driver of genetic intratumor heterogeneity.

Subramanian VenkatesanMihaela AngelovaJirina BartkovaSamuel F BakhoumJiri BartekNnennaya KanuCharles Swanton

Published in: Molecular & cellular oncology (2022)

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

Keyphrases

copy number
mitochondrial dna
single cell
genome wide
dna methylation
papillary thyroid
squamous cell
cell migration