Norcantharidin-Encapsulated C60-Modified Nanomicelles: A Potential Approach to Mitigate Cytotoxicity in Renal Cells and Simultaneously Enhance Anti-Tumor Activity in Hepatocellular Carcinoma Cells.

Zhongpeng DingBeihua XuHuimin ZhangZhenyu WangLuying SunMengjie TangMeihong DingTing ZhangSenlin Shi

Published in: Molecules (Basel, Switzerland) (2023)

The DSPE-PEG-C60/NCTD micelles, as prepared in this study, demonstrated the ability to decrease cytotoxicity and ROS levels in normal renal cells (HK-2) in vitro. Additionally, these micelles showed an enhanced antitumor activity against human hepatocellular carcinoma cells (HepG2, BEL-7402).

Keyphrases

induced apoptosis
drug delivery
cell cycle arrest
endothelial cells
cancer therapy
drug release
dna damage
endoplasmic reticulum stress
hyaluronic acid