Perampanel Reduces Brain Damage via Induction of M2 Microglia in a Neonatal Rat Stroke Model.
Hyo Jung ShinKa Young LeeJoon Won KangSeung Gyu ChoiDong Woon KimYoon Young YiPublished in: International journal of nanomedicine (2022)
PER-loaded PLGA nanoparticles decreased the size of the infarct and increased motor function in a perinatal ischemic stroke rat model. Pro-inflammatory cytokines were also reduced compared to the control group. Finally, this development of a drug delivery system targeting microglia confirms the potential to develop new therapeutic agents for perinatal ischemic stroke.
Keyphrases
- atrial fibrillation
- drug delivery
- inflammatory response
- cancer therapy
- pregnant women
- oxidative stress
- neuropathic pain
- cerebral ischemia
- resting state
- white matter
- acute myocardial infarction
- heart failure
- functional connectivity
- percutaneous coronary intervention
- spinal cord
- wound healing
- coronary artery disease
- left ventricular