Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma.

M J Hernández-EsparzaEmiliano Zampetti Sara Cerra Karla Juarez-Moreno Rafael Huirache-Acuña

Published in: Nanoscale advances (2023)

This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.

Keyphrases

gold nanoparticles
skin cancer
drug delivery
single cell
basal cell carcinoma
high dose
cell therapy
emergency department
stem cells
reduced graphene oxide
cell proliferation
wound healing
electronic health record