CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma.

Jiaji MaoJianing LiJunwei ChenQin WenMinghui CaoFang ZhangBaoxun LiQinyuan ZhangZhe WangJingzhong ZhangJun Shen

Published in: Journal for immunotherapy of cancer (2023)

MRI-guided peritumoral administration of CXCL10 and Nrf2-overexpressed MSCs can significantly limit GBM growth by revitalizing T lymphocytes within TME. The combination application of CXCL10-Nrf2-FTH-MSC transplantation and ICB therapy presents a potentially effective approach to treating GBM.

Keyphrases

mesenchymal stem cells
oxidative stress
umbilical cord
magnetic resonance imaging
bone marrow
contrast enhanced
magnetic resonance
diffusion weighted imaging