Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson's disease in Black South African and Nigerian patients.

Oluwafemi G OluwoleHelena KuivaniemiShameemah AbrahamsWilliam L HaylettAlvera A VorsterCarel J van HeerdenColin P KenyonDavid L TabbMichael B FawaleTaofiki A SunmonuAbiodun AjoseMatthew O OlaogunAnastasia C RossouwLudo S van HillegondsbergJonathan CarrOwen A RossMorenikeji A KomolafeGerard TrompSoraya Bardien

Published in: BMC medical genetics (2020)

We identified several rare variants predicted to be deleterious in sub-Saharan Africa PD patients; however, further studies are required to determine the biological effects of these variants and their possible role in PD. Studies such as these are important to elucidate the genetic aetiology of this disorder in patients of African ancestry.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
copy number
prognostic factors
peritoneal dialysis
patient reported outcomes