Propranolol suppresses gastric cancer cell growth by regulating proliferation and apoptosis.

Masahiro KohTsuyoshi TakahashiYukinori KurokawaTeruyuki KobayashiTakuro SaitoTomo IshidaSatoshi SeradaMinoru FujimotoTetsuji NakaNoriko WadaKotaro YamashitaKoji TanakaYasuhiro MiyazakiTomoki MakinoKiyokazu NakajimaMakoto YamasakiHidetoshi EguchiYuichiro Doki

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2021)

Propranolol inhibits the proliferation of gastric cancer cells by inducing G1-phase cell cycle arrest and apoptosis. These findings indicate that propranolol might have an opportunity as a new drug for gastric cancer.

Keyphrases

cell cycle arrest
signaling pathway
pi k akt
cell death
oxidative stress
cell proliferation