A nanoparticle-drug delivery system against Staphylococcus aureus , especially Methicillin-resistant staphylococcus aureus , has been recently proposed as an alternative pathway therapy. Methicillin-resistant staphylococcus aureus is resistance to many antibiotics, making it a a threat to human life, especially for older and immunocompromised people. Treatment of Multidrug-resistant staphylococcus aureus is considered an urgent need. A variety of kinds of nanoparticle-drug delivery systems with different compositions, and biological properties have been extensively investigated against Staphylococcus aureus . This review summarizes the novel nanoparticle-drug delivery systems against Staphylococcus aureus . These nanoparticle-drug delivery systems could reduce antibiotic resistance and minimize side effects of the antibiotics. Also, they can deliver a high concentration of the drugs and eliminate the bacteria in a specific and targeted site of infection. Despite these benefits of nanoparticle-drug delivery systems, the cytotoxicity, stress oxidative, genotoxicity, and inflammation that may occur in vivo and in vitro should not be ignored. Therefore, we need a better knowledge of the pharmacological properties and safety concerns of nanoparticle-drug delivery systems. The limitations of each nanoparticle-drug delivery system with high therapeutic potential have to be considered for further design.
Keyphrases
- staphylococcus aureus
- methicillin resistant staphylococcus aureus
- iron oxide
- multidrug resistant
- biofilm formation
- drug delivery
- healthcare
- physical activity
- oxidative stress
- pseudomonas aeruginosa
- escherichia coli
- drug resistant
- cancer therapy
- high resolution
- mesenchymal stem cells
- cystic fibrosis
- bone marrow
- mass spectrometry
- single molecule
- candida albicans
- cell therapy
- drug induced
- replacement therapy
- mechanical ventilation