Angiotensin Receptor-Neprilysin Inhibition (Sacubitril/Valsartan) Reduces Structural Arterial Stiffness in Middle-Aged Mice.
Isabel N SchellingerAngelika DannertAnnett HoffmannGiriprakash ChodisettiKarin MatternAnne PetzoldNora KlötingAndreas SchusterMarkus U WagenhäuserFabian EmrichMichael StumvollGerd HasenfußUwe RaazPublished in: Journal of the American Heart Association (2024)
This study provides preclinical mechanistic evidence indicating that ARNI-based interventions may counteract age-related arterial stiffening and may therefore be further investigated as a promising strategy to improve cardiovascular outcomes in the elderly.