Sulfated polysaccharides of some seaweeds exhibit neuroprotection via mitigation of oxidative stress, cholinergic dysfunction and inhibition of Zn - induced neuronal damage in HT-22 cells.
Tosin Abiola OlasehindeAdemola O OlaniranAnthony I OkohPublished in: BMC complementary medicine and therapies (2020)
PKPM, PGCL, PURL, PULV and PMNP exhibit neuroprotective effects against neuronal damage induced by Zn and this may be attributed to inhibition of apoptosis, oxidative damage and acetylcholinesterase activity. These polysaccharides may be good therapeutic agents to protect neuronal cells against Zn - induced pathological processes associated with Alzheimer's disease.
Keyphrases
- oxidative stress
- induced apoptosis
- diabetic rats
- cell cycle arrest
- endoplasmic reticulum stress
- cerebral ischemia
- cell death
- high glucose
- heavy metals
- ischemia reperfusion injury
- climate change
- signaling pathway
- pi k akt
- drug induced
- cognitive decline
- risk assessment
- endothelial cells
- blood brain barrier
- cell proliferation
- water soluble
- heat shock protein