Inhibitory growth evaluation and apoptosis induction in MCF-7 cancer cells by new 5-aryl-2-butylthio-1,3,4-oxadiazole derivatives.

Rashmin KhanamKamal AhmadIram I HejaziIbrar A SiddiqueVikash KumarAbdul Roouf BhatAmir AzamFareeda Athar

Published in: Cancer chemotherapy and pharmacology (2017)

Based on the results of in vitro studies, it could be concluded that compound 5e showed a significant inhibitory growth effect on MCF-7 cells and have the potential to be developed as lead molecule and further structural modifications may result in promising new anticancer agents.

Keyphrases

cell cycle arrest
induced apoptosis
breast cancer cells
cell death
endoplasmic reticulum stress
oxidative stress
risk assessment
cell proliferation
case control
structure activity relationship