PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial.
Sarah J KitsonZoe MaskellVanitha N SivalingamJennifer L AllenSaad AliSean BurnsKyle GilmourRahamatulla LatheefRichard J SladePhilip W PembertonJoseph ShawW David RyderHenry C KitchenerEmma J CrosbiePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Short-term treatment with standard diabetic doses of metformin does not reduce tumor proliferation in women with endometrioid endometrial cancer awaiting hysterectomy. This study does not support a biological effect of metformin in endometrial cancer and casts doubt on its potential application in the primary and adjuvant treatment settings.