Multi-omics integration reveals a core network involved in host defence and hyperkeratinization in psoriasis.

Chuanjian Lu Emmerik F A Leijten Michel Olde NordkampGuangjuan ZhengJuliëtte PouwWeiyang TaoSarita HartgringDeepak BalakRianne RijkenRunyue HuangTimothy RadstakeChuan-Jian Lu Aridaman Pandit

Published in: Clinical and translational medicine (2022)

We identified a core gene network that associated with local disease severity and microbiome composition, involved in the inflammation and hyperkeratinization in psoriatic skin.

Keyphrases

oxidative stress
rheumatoid arthritis
genome wide
copy number
ankylosing spondylitis
single cell
disease activity
wound healing
transcription factor
network analysis
genome wide identification