US Severe Acute Respiratory Syndrome Coronavirus 2 Epsilon Variant: Highly Transmissible but With an Adjusted Muted Host T-Cell Response.

Jasmine T PlummerDeisy ContrerasWenjuan ZhangAleksandra BinekRuan ZhangFelipe DezemStephanie S ChenBrian D DavisJorge Sincuir MartinezAleksandr StotlandSimion KreimerElias MakhoulSaleh HeneidiCeleste EnoBongha ShinAnders H BergSusan Chengnull nullStanley C JordanEric VailJennifer E Van EykMargie A Morgan

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

While the epsilon variant is more infectious, by altering viral processing, we showed that patients with COVID-19 have adapted their innate immune response to this fitter variant. A protective T-cell response molecular signature is generated by this more transmissible variant in both vaccinated and unvaccinated patients.

Keyphrases

respiratory syndrome coronavirus
sars cov
innate immune
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
coronavirus disease
peritoneal dialysis
prognostic factors
patient reported outcomes
single molecule