Chronic inflammatory diseases, myocardial function and cardioprotection.
Antigone LazouIgnatios IkonomidisMonika BartekovaTheodora BenedekGeorge MakavosDimitra PaliouraHector Alejandro Cabrera-FuentesIoanna AndreadouPublished in: British journal of pharmacology (2020)
The association between chronic inflammatory diseases (CIDs) and increased cardiovascular (CV) risk is well documented and can be a most threatening complication in these patients. However, the pathogenetic mechanisms underlying increased CV risk remain elusive, especially in their cellular and biochemical pathways. Using animal models to understand mechanisms underlying cardiac involvement are limited. Additionally, treatments may influence cardiovascular events through different outcomes. Some drugs used to treat CIDs can negatively affect cardiac function by a direct toxicity, whereas others may protect the myocardium. In the present article, we focus on the cardiac manifestations and risk factors, the pathogenetic mechanisms, and the effect of treatments on myocardial function and cardioprotection for five common worldwide CIDs (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, psoriasis and inflammatory bowel disease). We also give recommendations in order to evaluate common targets between CID and CV disease (CVD) and to design therapies to alleviate CID-related CVD. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc.
Keyphrases
- systemic sclerosis
- risk factors
- cardiovascular events
- left ventricular
- interstitial lung disease
- systemic lupus erythematosus
- rheumatoid arthritis
- oxidative stress
- disease activity
- end stage renal disease
- coronary artery disease
- ejection fraction
- newly diagnosed
- cardiovascular disease
- peritoneal dialysis
- prognostic factors
- heart failure
- metabolic syndrome
- patient reported outcomes
- idiopathic pulmonary fibrosis
- atrial fibrillation
- atopic dermatitis
- breast cancer risk