Undetectable anti-Mullerian hormone and inhibin B do not preclude the presence of germ cell tumours in 45,X/46,XY or 46,XY gonadal dysgenesis.
Sabine Elisabeth HannemaKatja P WolffenbuttelYolande van BeverHennie T BrüggenwirthSjoerd A A van den BergRemko HersmusJ Wolter OosterhuisLeendert H J LooijengaPublished in: Clinical endocrinology (2023)
Undetectable serum AMH and inhibin B cannot reliably predict the absence of germ cells and germ cell tumours in individuals with 45,X/46,XY or 46,XY gonadal dysgenesis. This information should help in counselling about prophylactic gonadectomy, taking into account both the germ cell cancer risk and potential for gonadal function.