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Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse.

Christian SecchiMartina BelliTracy N H HarrisonJoseph SwiftCheMyong KoAntoni J DulebaDwayne StupackR Jeffrey ChangShunichi Shimasaki
Published in: Journal of translational medicine (2021)
Our novel mouse model is a versatile tool to provide innovative insights into study the effects of Cyp17 overexpression and hyperandrogenism in the ovary.
Keyphrases
  • mouse model
  • cell proliferation
  • transcription factor
  • single cell
  • polycystic ovary syndrome
  • metabolic syndrome
  • insulin resistance
  • mesenchymal stem cells