Association of renin-angiotensin-aldosterone system gene polymorphisms with left ventricular hypertrophy in patients with heart failure with preserved ejection fraction: A case-control study.

Ehsan Bahramali Negar FirouzabadiMona RajabiAlireza ManafiMehrdad ZarghamiSeyyed Mohammad MousaviJavad Jamshidi

Published in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2017)

Increased ACE activity explains the significant association of rs4343 and rs4291 polymorphisms with LVH in the carriers. Furthermore, findings support the pathophysiologic links between RAAS and increased LV mass in hypertension and suggest a genetic susceptibility to HFpEF. Such polymorphisms may serve as risk predictors of HFpEF in hypertensive patients.

Keyphrases

blood pressure
hypertensive patients
angiotensin converting enzyme
angiotensin ii
left ventricular
heart failure
mitral valve
copy number
cardiac resynchronization therapy
acute coronary syndrome